//www.pyrotek-europe.com/cancer-news/ en-us The latest news on cancer, health, medicines, cancer treatments, cancer research, cancer studies and types of cancer. Immunotherapy is one of the most promising approaches to inhibit tumor growth and metastasis by activating host immune functions. However, so far, immunotherapy still exhibits limitations of efficacy and safety, such as huge individual differences in treatment responses, difficulty to work on solid tumors, systemic immune storm and other immunotoxicity.//www.pyrotek-europe.com/news/2021-01-macrophage-based-drug-antitumor-immunotherapy.html Oncology & Cancer Mon, 18 Jan 2021 07:27:30 EST news530177248 Scientists from the University of Granada and GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), in a study led by Juan Carlos Rodríguez-Manzaneque, have demonstrated the significant role of a protein called ADAMTS1 in uveal melanoma, one of the rarest and most aggressive cancers that exist, which develops in the eye.//www.pyrotek-europe.com/news/2021-01-scientists-role-protein-adamts1-rare.html Oncology & Cancer Fri, 15 Jan 2021 13:44:08 EST news529940645 In a large study of pediatric cancer patients, researchers from Children's Hospital of Philadelphia (CHOP) have analyzed the frequency, fusion partners, and clinical outcome of neurotrophic tyrosine receptor kinase (NTRK) fusions, which are clinical biomarkers that identify patients suitable for treatment with FDA-approved TRK inhibitors. The researchers found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors.//www.pyrotek-europe.com/news/2021-01-ntrk-fusions-common-pediatric-tumors.html Oncology & Cancer Fri, 15 Jan 2021 11:51:58 EST news529933908 In the 1920s, German chemist Otto Warburg discovered that cancer cells don't metabolize sugar the same way that healthy cells usually do. Since then, scientists have tried to figure out why cancer cells use this alternative pathway, which is much less efficient.//www.pyrotek-europe.com/news/2021-01-longstanding-cancer-cells-energy-fermentation.html bob88体育平台登录 Fri, 15 Jan 2021 09:24:24 EST news529925057 Cancer is a notoriously complex disease, in part because it may be caused by mutations among hundreds or even thousands of genes. In addition, most cancers exhibit an extraordinary amount of variation among genetic mutations, even between patients with the same types of cancers.//www.pyrotek-europe.com/news/2021-01-method-disrupted-pathways-cancer.html Oncology & Cancer Fri, 15 Jan 2021 09:18:12 EST news529924689 Researchers at the Center for Computational Imaging and Personalized Diagnostics (CCIPD) at Case Western Reserve University have preliminarily validated an artificial intelligence (AI) tool to predict how likely the disease is to recur following surgical treatment for prostate cancer.//www.pyrotek-europe.com/news/2021-01-artificial-intelligence-tool-mri-scans.html Oncology & Cancer Fri, 15 Jan 2021 09:15:41 EST news529924536 At its onset, the COVID-19 pandemic severely disrupted medical care, as millions of elective procedures were postponed or canceled. While the volume of many procedures rebounded by the end of July 2020, the disruption caused a massive backlog. In a recent article in Health Services Research, LDI Associate Fellow and postdoctoral researcher Alon Bergman and his co-authors study the impact of the COVID-19 pandemic on one common procedure, mammograms, and answer the question: When might we expect to clear the queue and return to regular operations?//www.pyrotek-europe.com/news/2021-01-backlog-mammograms-covid-pandemic.html Oncology & Cancer Fri, 15 Jan 2021 07:30:01 EST news529917819 Our biological or circadian clock synchronizes all our bodily processes to the natural rhythms of light and dark. It's no wonder then that disrupting the clock can wreak havoc on our body. In fact, studies have shown that when circadian rhythms are disturbed through sleep deprivation, jet lag, or shift work, there is an increased incidence of some cancers including prostate cancer, which is the second leading cause of cancer death for men in the U.S. With an urgent need to develop novel therapeutic targets for prostate cancer, researchers at the Sidney Kimmel Cancer—Jefferson Health (SKCC) explored the circadian clock and found an unexpected role for the clock gene CRY-1 in cancer progression. The study was published on January 15th in Nature Communications.//www.pyrotek-europe.com/news/2021-01-unexpected-prostate-cancerour-biological-clock.html Oncology & Cancer Fri, 15 Jan 2021 05:00:01 EST news529906712 研究人员希望,一个举世闻名的印度pendent research and treatment center for cancer, diabetes and other life-threatening diseases, have developed a tool that could predict if older adults with early-stage breast cancer will develop a severe or deadly reaction to chemotherapy.//www.pyrotek-europe.com/news/2021-01-tool-chemotherapy-debilitating-side-effects.html Oncology & Cancer Fri, 15 Jan 2021 03:09:40 EST news529902568 Waldenström macroglobulinemia (WM), a rare form of lymphoma, does not have any known cure and only one FDA-approved treatment making it challenging to treat patients. Researchers at the University of New Hampshire took the novel approach of targeting specific cell proteins that control DNA information using inhibitors, or drugs, that were effective in reducing the growth of the cancer cells and when combined with a third drug were even more successful in killing the WM cancer cells which could lead to more treatment options.//www.pyrotek-europe.com/news/2021-01-inhibitor-drug-combination-rare-cancer.html Oncology & Cancer Thu, 14 Jan 2021 16:35:13 EST news529864507 As cancer and tumor cells move inside the human body, they impart and are subject to mechanical forces. In order to understand how these actions affect cancer cell growth, spread, and invasion, a team of engineers at Rensselaer Polytechnic Institute is developing new models that mimic aspects of the mechanical environment within the body, providing new insight into how and why tumors develop in certain ways.//www.pyrotek-europe.com/news/2021-01-cancer-mechanical-insight-tumor-growth.html Oncology & Cancer Thu, 14 Jan 2021 16:24:17 EST news529863853 New research from CU Cancer Center member Jing Hong Wang, MD, Ph.D., and recent University of Colorado Immunology program graduate Rachel Woolaver, Ph.D., may help researchers develop more effective personalized immunotherapy for cancer patients.//www.pyrotek-europe.com/news/2021-01-role-cells-cancer.html Oncology & Cancer Thu, 14 Jan 2021 16:21:07 EST news529863664 基于临床前研究的临床实验drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1). The results of the Phase 2 clinical trial, co-chaired by Michael J. Fisher, MD at CHOP, were published recently in Nature Medicine.//www.pyrotek-europe.com/news/2021-01-efficacy-treatment-neurofibromatosis-related-tumors.html bob88体育平台登录 Thu, 14 Jan 2021 14:01:52 EST news529855306 The new, Oxford-developed method for subtyping ovarian cancer has been validated in a recent collaboration between the University of Oxford and Imperial College London. Dubbed the "Oxford Classic," researchers have demonstrated that it enables the accurate prediction of patient disease outcome, as well as the development of new targeted cancer therapies.//www.pyrotek-europe.com/news/2021-01-accurate-ovarian-cancer-outcome-classification.html Oncology & Cancer Thu, 14 Jan 2021 13:35:08 EST news529853705 Leading cancer experts at the University of Birmingham have solved a long-standing question of how various types of mutations in just one gene cause different types of diseases.//www.pyrotek-europe.com/news/2021-01-cancer-reveals-mutations-specific-gene.html Oncology & Cancer Thu, 14 Jan 2021 13:29:34 EST news529853370 In patients with bladder cancer, chemotherapy effectiveness is partially determined by the body's immune system response to the malignancy. This is the conclusion of research conducted by a team of scientists from Charité - Universitätsmedizin Berlin and the Berlin Institute of Health. The findings, which have been published in Science Translational Medicine, can be used to predict treatment success and may increase survival in patients with bladder cancer.//www.pyrotek-europe.com/news/2021-01-bladder-cancerwhen-chemotherapy.html Oncology & Cancer Thu, 14 Jan 2021 12:33:30 EST news529850005 The hallmarks of cancer include rapid cell reproduction and metabolic activity. But these processes also lead to increased cellular stress and oxidation, and the risk of cell death. To circumvent these negative consequences of supercharged growth, cancer cells stimulate pathways to reduce oxidative stress and avoid cell death. In an article published in Cell Metabolism, Moffitt Cancer Center researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis.//www.pyrotek-europe.com/news/2021-01-biochemical-pathway-cells-ferroptosis.html Oncology & Cancer Thu, 14 Jan 2021 12:33:11 EST news529849987 Numerous studies in mice and cancer cells have shown cancer growth can be reduced in response to diets lacking serine. But results have been variable because some cancer cells are efficient in making their own serine, particularly those with a KRAS mutation which is found in several hard-to-treat cancers.//www.pyrotek-europe.com/news/2021-01-scientists-approach-exploiting-cancer-dietary.html Oncology & Cancer Thu, 14 Jan 2021 11:40:01 EST news529846796 In one of the first studies to examine the impact of the COVID-19 pandemic on cancer diagnoses, researchers at Dana-Farber/Brigham and Women's Cancer Center document a substantial decline in cancer and precancer diagnoses at the Northeast's largest health care system during the first peak of the pandemic because of a drop in the number of cancer screening tests performed.//www.pyrotek-europe.com/news/2021-01-sharp-decline-cancer-screenings-covid-.html Oncology & Cancer Thu, 14 Jan 2021 11:00:05 EST news529830793 Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response. A new study published in Cell shows that endogenous mis-spliced RNA in tumor cells mimics an RNA virus, leading tumor cells to self-destruct as if fighting an infection. Researchers suggest this mechanism could open new avenues for turning on the immune system in aggressive cancers like TNBC.//www.pyrotek-europe.com/news/2021-01-triggering-tumor-antiviral-immune-response.html Oncology & Cancer Thu, 14 Jan 2021 11:00:02 EST news529841887 According to ARRS' American Journal of Roentgenology (AJR), new suspicious findings occurred in 5.5% of breast MRI examinations performed to monitor response to neoadjuvant therapy; none of these new lesions were malignant.//www.pyrotek-europe.com/news/2021-01-suspicious-lesions-breast-mri-neoadjuvant.html Oncology & Cancer Thu, 14 Jan 2021 10:47:41 EST news529843657 It is increasingly clear that the trillions of bacteria that make themselves at home in and on the human body are more than just casual observers along for the ride. Gut bacteria in particular have been shown to have an enormous influence on human health, with studies suggesting they play a role in illnesses ranging from autoimmune disorders to anxiety and depression.//www.pyrotek-europe.com/news/2021-01-esophageal-cancer-patients-abundance-oral.html Oncology & Cancer Thu, 14 Jan 2021 10:46:19 EST news529843576 Researchers at McGill University have identified a new cellular pathway that limits the growth and spread of brain tumors by controlling the recycling of cell surface receptor proteins. The study, which will be published January 14 in the Journal of Cell Biology (JCB), suggests that the pathway, which involves a protein called Rab35, is defective in many patients with glioblastoma and that restoring Rab35's activity could be a new therapeutic strategy for this deadly form of brain cancer.//www.pyrotek-europe.com/news/2021-01-link-cellular-pathway-aggressive-brain.html Oncology & Cancer Thu, 14 Jan 2021 10:00:02 EST news529833089 The hematopoietic (blood-forming) stem cells (HSCs) residing in our bone marrow produce all of our blood cells, including key immune cells that protect us from bacteria and viruses. As we age, our HSCs become less efficient and less able to make healthy new blood cells. In a study published online today in Nature, researchers at Albert Einstein College of Medicine have found that this reduction in HSC efficiency is caused in part by the deterioration of chaperone-mediated autophagy (CMA), the housekeeping process that removes damaged proteins and other waste materials that interfere with cells' ability to function.//www.pyrotek-europe.com/news/2021-01-strategy-blood-stem-cells-healthier.html bob88体育平台登录 Thu, 14 Jan 2021 09:18:53 EST news529838326 Completing cancer screening tests, such as mammograms, can be challenging for low-income people, who may face such challenges as lack of transportation or inability to take time off work. A team at Massachusetts General Hospital (MGH) explored the possibility of addressing preventive care needs when patients are admitted to the hospital.//www.pyrotek-europe.com/news/2021-01-inpatient-mammograms-disparities-breast-cancer.html Oncology & Cancer Wed, 13 Jan 2021 16:20:00 EST news529777197 In a new study, researchers show that a light-based analytical technique known as Raman spectroscopy could aid in early detection of oral squamous cell carcinoma (OSCC).//www.pyrotek-europe.com/news/2021-01-raman-spectroscopy-oral-cancer.html Oncology & Cancer Wed, 13 Jan 2021 12:38:26 EST news529763903 New research in the January 2021 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds more than a third of eligible people miss timely screening tests for colorectal cancer and at least a quarter appear to miss timely screening tests for breast and cervical cancers. The study comes from the University of Alberta, Faculty of Medicine and Dentistry in Alberta, Canada, with findings based on self-reported results from the Canadian Community Health Survey (CCHS) from 2007-2016. According to the author, the results also point to evidence of screening disparities being linked to lower socioeconomic status and identifiable minority race—echoing a similar study conducted in the United States by the Centers for Disease Control.//www.pyrotek-europe.com/news/2021-01-highlights-dangerous-disparities-life-saving-cancer.html Oncology & Cancer Wed, 13 Jan 2021 10:58:58 EST news529757934 Research from Te Herenga Waka—Victoria University of Wellington has shown the offer of an HPV self-test could increase the uptake of cervical screening by almost three times for under-screened Māori women.//www.pyrotek-europe.com/news/2021-01-self-administered-cervical-screening-lifesaving-potential.html Oncology & Cancer Wed, 13 Jan 2021 09:26:03 EST news529752360 Financial toxicity (FT) is associated with worse quality of life (QOL) for breast cancer patients after mastectomy or lumpectomy, according to a study published online Dec. 11 in the Journal of the American College of Surgeons.//www.pyrotek-europe.com/news/2021-01-financial-toxicity-linked-quality-life.html Oncology & Cancer Wed, 13 Jan 2021 07:40:01 EST news529744710 Glioblastoma brain tumors are especially perplexing. Inevitably lethal, the tumors occasionally respond to new immunotherapies after they've grown back, enabling up to 20% of patients to live well beyond predicted survival times.//www.pyrotek-europe.com/news/2021-01-recurrent-gbm-brain-tumors-mutations.html Oncology & Cancer Wed, 13 Jan 2021 05:00:01 EST news529735191